In a large cast iron skillet, add oil halfway up the side. Heat oil to 375 degrees.
In a medium bowl, add 1 cup of cornmeal and one cup flour.
In a small bowl, add paprika, black pepper, garlic powder, onion powder, and cayenne pepper. Stir until thoroughly mixed. Add 3 tablespoons of the spice mixture to the flour cornmeal mixture.
To make the wet mixture, in a medium bowl add remaining cornmeal and flour, mustard, eggs, hot sauce, and the remaining spice mixture and mix thoroughly. Add the fish fillets to the wet mixture and completely coat each fillet.
When oil has reached 350 degrees, coat 2 fillets with flour cornmeal mixture. Place the fillets in the hot oil and cook until fish is golden brown and cooked through, about 7 minutes. Remove fillets to a cooling rack placed on top of a cookie sheet.
Repeat with the remaining fillets and drain on the cooling rack.